Kava Interactions with Common Substances
Based on our thorough search on Kava (Piper methysticum plant) which has been used for centuries in traditional ceremonies and as a natural remedy for stress and anxiety. However, kava-kava can interact with a wide range of substances, including alcohol, psychoactive substances, OTC and prescriptions, potentially leading to dangerous combinations or risk of side effects.
Important: While we cannot list every possible compound / medication that interacts with Kava Kava, here are the top most common substances that may have interactions when combined with Kava (Piper methysticum plant)
| Substance | Interaction | Warning |
|---|---|---|
| Alcohol | It's unsafe to take kava with alcohol. |
 DANGEROUS |
| Psychoactive drugs | Dangerous combination. Kava should not be used with other psychoactive drugs. |
DANGEROUS |
| Prescription medications | Potential interactions. It's best to avoid kava if taking any prescription medicine due to limited information on interactions. |
POTENTIAL RISK |
| Antidepressants | High risk. Kava is especially risky if you take antidepressants. |
HIGH RISK |
| Dopaminergic drugs | Kava interacts with the D2 receptor, which may affect drugs that target dopamine. |
POTENTIAL RISK |
| GABA-affecting drugs | There is a potential interaction since Kava interacts with GABA receptors, which may affect drugs that target GABA. |
POTENTIAL RISK |
| Opioids | Potential interaction: Kava Kava interacts with opioid receptors, which may affect opioid medications. |
POTENTIAL RISK |
| Antihistamines | Potential interaction: Kava interacts with H1 and H2 receptors, which may affect antihistamine medications. |
POTENTIAL RISK |
Feel free to learn more about the best Kava drinks and supplements reviewed by Sunset City as well as all the Kava strains available on the market.
ALL INFORMATIONAL content on this site is only for research purposes, please consult with a doctor or professional before consuming any substances that you aren't familiar with!
